CLINICAL TRIALS AND OBSERVATIONS Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
نویسندگان
چکیده
Nicolaus Kröger,1 Ernst Holler,2 Guido Kobbe,3 Martin Bornhäuser,4 Rainer Schwerdtfeger,5 Herrad Baurmann,5 Arnon Nagler,6 Wolfgang Bethge,7 Matthias Stelljes,8 Lutz Uharek,9 Hannes Wandt,10 Andreas Burchert,11 Paolo Corradini,12 Jörg Schubert,13 Martin Kaufmann,14 Peter Dreger,15 Gerald G. Wulf,16 Hermann Einsele,17 Tatjana Zabelina,1 Hans Michael Kvasnicka,18 Jürgen Thiele,18 Ronald Brand,19 Axel R. Zander,1 Dietger Niederwieser,20 and Theo M. de Witte21
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes
Rodrigo Martino, Simona Iacobelli, Ronald Brand, Thekla Jansen, Anja van Biezen, Jürgen Finke, Andrea Bacigalupo, Dietrich Beelen, Jossy Reiffers, Agnes Devergie, Emilie Alessandrino, Ghulam J. Mufti, Renée Barge, Jorge Sierra, Tapani Ruutu, Marc Boogaerts, Michele Falda, Jean-Pierre Jouet, Dieter Niederwieser, and Theo de Witte, for the Myelodysplastic Syndrome subcommittee of the Chronic Leuk...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT
This study reports outcomes of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning (RIC) in 186 patients with chronic myeloid leukemia (CML) from the European Group for Blood and Marrow Transplantation (EBMT). The median age was 50 years, and 64% were in first chronic phase (CP1), CP2 13%, accelerated phase 17%, and blast crises 6%. The median EBMT transplant ...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Allogeneic hematopoietic cell transplantation after conditioning with 131I–anti-CD45 antibody plus fludarabine and low-dose total body irradiation for elderly patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndrome
We conducted a study to estimate the maximum tolerated dose (MTD) of 131I– anti-CD45 antibody (Ab; BC8) that can be combined with a standard reduced-intensity conditioning regimen before allogeneic hematopoietic cell transplantation. Fiftyeight patients older than 50 years with advanced acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) were treated with 131I-BC8 Ab and fl...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Outcomes after alemtuzumab-containing reduced-intensity allogeneic transplantation regimen for relapsed and refractory non-Hodgkin lymphoma
We report the outcomes after reducedintensity conditioning allogeneic stem cell transplantation (RIT) for non-Hodgkin lymphoma (NHL) in 88 patients (low-grade NHL [LG-NHL], n 41; high-grade NHL [HG-NHL], n 37; mantle cell lymphoma [MCL], n 10). Thirty-seven patients had previously received autografts, and 21 were in complete remission (CR) at transplantation. Conditioning therapy consisted of a...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase
Reduced-intensity or nonmyeloablative stem cell transplantation (NST) is designed to induce host-versus-graft tolerance by engraftment of donor stem cells. The rationale behind NST is to induce optimal graft-versus-leukemia (GVL) effects for elimination of all malignant cells by donor alloreactive immunocompetent cells as an alternative to standard highdose myeloablative chemoradiotherapy. NST ...
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